There exist multiple decks playing Urzas Saga, the most popular being Affinity, Amulet Titan and Hammer Time, and Force of Vigor can regularly destroy two permanents for zero mana in these matchups
And in this case there's no such thing as too much of a good thing: Your deck or sideboard can certainly include both if you need to
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Omniscience was very scary in game 1, but became totally manageable after sideboarding