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which demonstrated that Bardoxolone methyl administration significantly decreased megalin protein expression in the monkey kidney
PubMed PMID: 29299164
6(4):699-706
Inhibition of MMPs and ADAM/ADAMTS
PF-04929113 free base sgenin which demonstrated that Bardoxolone methylPF 04929113, also known as SNX 5422; is a synthetic prodrug targeting the human heat shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX 5542 is rapidly converted to SNX 2112, which accumulates in tumors relative to normal tissues. SNX 2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2 ERBB2,
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