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in patients with advanced solid malignancies
PubMed PMID: 29193663
2010 Sep 22
PLX-4720 treatment at 30 mg/kg/day significant inhibits the tumor growth of 8505c xenografts by >90%
Bedaquiline Catalog No.:M8161-2 in patients with advanced solidBedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.
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