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Ecteinascidin 743
Wistar Han rats 3
AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM
Formula: C28H33N5O3
AL 8810 isopropyl ester pyl Ecteinascidin 743EC50: 430 nM AL 8810 is a a FP receptor antagonist. Prostaglandin F receptor (FP), a receptor belonging to the prostaglandin (PG) group of receptors, binds to and mediates the biological actions of Prostaglandin F2 (PGF2). In vitro: Previous study found that AL 8810 had weak agonist potency in A7r5 cells and 3T3 fibroblasts. AL 8810 exhibited properties of an apparent competitive antagonist, which was demonstrated by producing parallel dextral shifts