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oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
LDE225 was used at 1 µM final concentration in cellular assays
Formula: C25H31N5O4
51(1):17-20
TAS-116 - CAS# 1260533-36-5 Catalog No.:M6713-10 oral multi-AGC kinase inhibitor withTAS 116, CAS No. 1260533 36 5, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo radiosensitizing activities. TAS 116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent signaling, induces apoptosis, and