AGI-6780 - Mutant IDH2 Inhibitor. CAS# 1432660-47-3 60218 either Fbxw7+/+ or Fbxw7mut/+

Name: AGI-6780 - Mutant IDH2 Inhibitor. CAS# 1432660-47-3 60218 either Fbxw7+/+ or Fbxw7mut/+
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Description

either Fbxw7+/+ or Fbxw7mut/+

311 nM and 39 nM for PI3Kα

(2012) AACR Annual Meeting: Chicago

InChi: InChI=1S/C28H38N6O2

AGI-6780 - Mutant IDH2 Inhibitor. CAS# 1432660-47-3 60218 either Fbxw7+/+ or Fbxw7mut/+AGI 6780, CAS No. 1432660 47 3, is a potent and selective IDH2 inhibitor. AGI 6780 inhibits the tumor associated mutant IDH2 R140Q. Treatment with AGI 6780 induced differentiation of TF 1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2 R140Q could have potential applications as a differentiation therapy for cancer. Product information CAS Number: 1432660 47 3 Molecular Weight: 481. 51

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