![Plinabulin Catalog No.:M10736-2 Smiles: CC1=CC(NC2=CC=C(F)C(C[C@@]3(C[C@@H](C)N(CC3)CC3=CC=CC(Cl)=C3F)C(O)=O)=N2)=NN1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10736_1621562383.gif?v=1621562384)
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Smiles: CC1=CC(NC2=CC=C(F)C(C[C@@]3(C[C@@H](C)N(CC3)CC3=CC=CC(Cl)=C3F)C(O)=O)=N2)=NN1
Formula: C26H22Cl2N2O
Chemical Name: N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2-[(5-methyl-1
Smiles: [O-][N+](=O)C1C=CC(=CC=1)C1=CC=C(/C=C2\C=C(C3C=CC=CC=3)N(C3C=CC(=CC=3)C(O)=O)C\2=O)O1
Plinabulin Catalog No.:M10736-2 Smiles: CC1=CC(NC2=CC=C(F)C(C[C@@]3(C[C@@H](C)N(CC3)CC3=CC=CC(Cl)=C3F)C(O)=O)=N2)=NN1MBRI 001 is a deuterium substituted plinabulin derivative as a potent anti cancer agent. MBRI 001 exhibited better pharmacokinetic characteristics than that of plinabulin. Additionally, its antitumor activity is in a low nanomolar level for a variety of cancer cell lines and high activity against human NCI H460 xenograted in mice intravenous administration. Importantly, continuous administration of MBRI 001 exhibited lower toxicity compared to