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InChi: InChI=1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7
WITHDRAWN: Celecoxib for rheumatoid arthritis
Its superior potency is associated with its increased enzyme residence time and prolonged cellular effects after washout
1610358-56-9 ((+)BAY-1251152)
AMG 925 altirelin InChi: InChI=1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7FLX925, also known as AMG 925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD D835, 28 nM; MV4 11ITD, 16 nM; MV4 11ITD D835, 19 nM; MV4 11ITD N841, 16 nM; MV4 11ITD F691, 73 nM). Product information CAS Number: 1401033 86 0 Molecular Weight: 471. 55 Formula:
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