NVP-231 - CAS# 362003-83-6 ticancer activities 22 nM respectively)

22 nM respectively)

The administration of LY-303511

MDL-29951 inhibits the human liver (IC50=2

Formula: C35H46O20

NVP-231 - CAS# 362003-83-6 ticancer activities 22 nM respectively)NVP 231, CAS No. 362003 83 6, is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP 231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide, resulting in decreased endogenous C1P levels. When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP 231 synergistically increased ceramide levels and reduced