MD-224 - CAS# 2136247-12-4 d Library of Histone Demethylase A novel aminothiazole KY-05009 with

A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

MD-224 - CAS# 2136247-12-4 d Library of Histone Demethylase A novel aminothiazole KY-05009 withMD 224, CAS No. 2136247 12 4, is a First in Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. MD 224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. It achieves an IC50 value of 1. 5 nM in inhibition of growth of RS4; 11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines.